StressMarq/AZD6244/SIH-495-25MG/25-mg
商品编号：
SIH-495-25MG
市场价：
¥9500.00
美元价：
5700.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | AZD6244 |
| Description | ERKkinaseinhibitor |
| Purity | >98% |
| CASNo. | 606143-52-6 |
| MolecularFormula | C17H15BrClFN4O3 |
| MolecularWeight | 457.7 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(92mg/mlat25°C),water(<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C) |
| Source | Synthetic |
| Appearance | Whitetooff-whitesolid |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| InChI | InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChIKey | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| SafetyPhrases | Classification:SeriousEyeDamage/EyeIrritation,Category1SkinSensitization,Category1ToxicToReproduction,Category2TargetOrganSystemicToxicity(repeatedexposure),Category2SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H318:Causesseriouseyedamage.H317:Maycauseanallergicskinreaction.H361:SUSPectedofdamagingfertilityortheunbornchild.H373:Maycausedamageto{Liver,gastrointestinaltractandothermajororgans}throughprolongedorrepeatedexposure.Precautionarystatements:P280:Wear{protectivegloves/protectiveclothing/eyeprotection/faceprotection}.P261:Avoidbreathing{dust/fume/gas/mist/vapours/spray}.P272:ContaminatedworkclothingshouldnotbeallowedoutoftheworKPLace.P362+364:Takeoffcontaminatedclothingandwashitbeforereuse.P201:Obtainspecialinstructionsbeforeuse.P202:Donothandleuntilallsafetyprecautionshavebeenreadandunderstood.P281:Usepersonalprotectiveequipmentasrequired.P260:Donotbreathe{dust/fume/gas/mist/vapours/spray}.P305+351+338:IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P310:Immediatelycalla{POISONCENTER/doctor/...}.P302+352:IFONSKIN:Washwithplentyofsoapandwater.P333+313:Ifskinirritationorrashoccurs,seekmedicaladvice/attention.P308+313:IFexposedorconcerned:Getmedicalattentiodvice.P314:Getmedicalattentiodviceifyoufeelunwell. |
| CiteThisProduct | AZD6244(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-495) |
BIOLOGicalDescription
| AlternativeNames | Selumetinib,AZD6244,6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 10127622 |
| ScientificBackground | AZD6244isaMEK-1inhibitor.Specifically,AZD6244inactivatesthephosphorylationofERK1/2. |
| References | 1.HaasbachE.,HartmayerC.,&PlanzO.(2013)AntiviralResearch.98(2):319–324. |
ProductImages
ChemicalstructureofAZD6244(SIH-495),aERKkinaseinhibitor.CAS#:606143-52-6.MolecularFormula:C17H15BrClFN4O3.MolecularWeight:457.7g/mol.
ProductCitations(0)
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
