StressMarq/Anti-Aquaporin 4 Antibody/SPC-505D-HRP/100-µg-免疫在线蚂蚁淘旗下平台

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商品详细StressMarq/Anti-Aquaporin 4 Antibody/SPC-505D-HRP/100-µg

StressMarq/Anti-Aquaporin 4 Antibody/SPC-505D-HRP/100-µg

商品编号： SPC-505D-HRP

品牌： StressMarq Biosciences

市场价： ¥6580.00

美元价： 3948.00

产地：美国(厂家直采)

公司：

产品分类：酚

公司分类： hydroxybenzene

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Overview:

ProductName Aquaporin4Antibody

Description

RabbitAnti-RatAquaporin4Polyclonal

SpeciesReactivity Human,Mouse,Rat

Applications WB,IHC,ICC/IF

AntibodyDilution WB(1:2000),IHC(1:200),ICC/IF(1:400);optimaldilutionsforassaysshouldbedeterminedbytheuser.

HostSpecies Rabbit

ImmunogenSpecies Rat

Immunogen ProducedagainsttheC-terminalpeptide(SequenceN-CTKGSYMEVEDNRSQVETED)ofrataquaporin4

Concentration 1mg/ml

Conjugates

AlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,Unconjugated

Properties

StorageBuffer	PBS,50%glycerol,0.09%sodiumazide
StorageTemperature	-20ºC
ShippingTemperature	BlueIceor4ºC
Purification	ProteinApurified
Clonality	Polyclonal
Specificity	Detects~35kDa.Maydetectlargerglycosylatedbands~50kDa.
CiteThisProduct	StressMarqBiosciencesCat#SPC-505,RRID:AB_10963604
CertificateofAnalysis	0.5µg/mlofSPC-505wassufficientfordetectionofaquaporin4in10µgofratkidneytissuelysatebycolorimetricimmunoblotanalysisusingGoatanti-rabbitIgG:HRPasthesecondaryantibody.

BIOLOGicalDescription

AlternativeNames	AQP4Antibody,AQP-4Antibody,AQP4Antibody,AQP4_HUMANAntibody,Aquaporintype4Antibody,Aquaporin-4Antibody,Aquaporin4Antibody,HMIWC2Antibody,HMIWC2Antibody,MercurialinsensitivewaterchannelAntibody,Mercurial-insensitivewaterchannelAntibody,MGC22454Antibody,MIWCAntibody,WCH4Antibody,WCH4Antibody
ResearchAreas	Aquaporins,IonChannels,Neuroscience
CellularLocalization	Membrane
AccessionNumber	NP_036957.1
GeneID	25293
SwissProt	P47863
ScientificBackground	Aquaporinsselectivelyconductwatermoleculesinandoutofthecell,whilepreventingthepassageofionsandothersolutes.Knownaswaterchannels,theyareintegralmembraneporeproteins(1,2).Aquaporin4isconstitutivelyexpressedinthebasolateralcellmembraneofprincipalcollectingductcellsinthekidneyandprovideapathwayforwatertoexitthesecells(3).ItisalsoexpressedinastrocytesandisupregulatedbydirectinsulttotheCNS(4).Aquaporin4hasbeenproposedastheprimaryautoimmunetargetinneuromyelitisoptica(5,6).
References	1.GonenT.,WalzT.(2006)Q.Rev.Biophys.39(4):361-396. 2.KnepperM.A.(1994)ProcNatl.AcadSci.USA.91(14):6255-6258. 3.AgreP.,NielsenS.(1996)Nephrologie.17(7):409-415. 4.NagelhusE.A.,MathiisenT.M.,OttersenO.P.(2004)Neuroscience.129(4):905-913. 5.LennonV.A.,KryzerT.J.,PittockS.J.,VerkmanA.S.,HinsonS.R.(2005)JExpMed.202(4):473-477. 6.BradlM.,LassmannD.H.(2008)Int.MSJournal/MSForum.15(3):75-78.

ProductImages

<p>Immunohistochemistry analysis using Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505). Tissue: kidney tissue. Species: Rat. Primary Antibody: Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505) at 1:200. Secondary Antibody: FITC Goat Anti-Rabbit (green).</p>

ImmunohistochemistryanalysisusingRabbitAnti-Aquaporin4PolyclonalAntibody(SPC-505).Tissue:kidneytissue.Species:Rat.PrimaryAntibody:RabbitAnti-Aquaporin4PolyclonalAntibody(SPC-505)at1:200.SecondaryAntibody:FITCGoatAnti-Rabbit(green).

<p>Western blot analysis of Rat kidney inner medullary homogenates showing detection of Aquaporin 4 protein using Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505). Primary Antibody: Rabbit Anti-Aquaporin 4 Polyclonal Antibody (SPC-505) at 1:2000.</p>

WesternblotanalysisofRatkidneyinnermedullaryhomogenatesshowingdetectionofAquaporin4proteinusingRabbitAnti-Aquaporin4PolyclonalAntibody(SPC-505).PrimaryAntibody:RabbitAnti-Aquaporin4PolyclonalAntibody(SPC-505)at1:2000.

ProductCitations(1)

InhibitionofMitochondrialComplex-1RestorestheDownregulationofAquaporinsinObstructiveNephropathy.

Sun,Y.etal.(2016)AmJPhysiolRenalPhysiol.311(4):F777-F786.

PubMedID:27413198

HRP(HorserADIshperoxidase)

Properties:

Enzymaticactivityisusedtoamplifyweaksignalsandincreasevisibilityofatarget
Readilycombineswithhydrogenperoxide(H₂O₂)toformHRP-H₂O₂complexwhichcanoxidizevarioushydrogendonors
Catalyzestheconversionof:
- Chromogenicsubstrates(e.g.TMB,DAB,ABTS)intocolouredproducts
- Chemiluminescentsubstrates(e.g.luminolandisoluminol)intolightemittingproductsviaenhancedchemiluminescence(ECL)
- Fluorogenicsubstrates(e.g.tyramine,homovanillicacid,and4-hydroxyphenylaceticacid)intofluorescentproducts
Highturnoverrateenablesrapidgenerationofastrongsignal
44kDaglycoprotein
Extinctioncoefficient:100(403nm)
Applications:Westernblot,immunohistochemistry,andELISA

HRPDatasheet

品牌介绍

StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。

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