StressMarq/Apicidin/SIH-346-5MG/5-mg
商品编号：
SIH-346-5MG
市场价：
¥4920.00
美元价：
2952.00
产品分类：
酚
公司分类：
hydroxybenzene
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Apicidin |
| Description | HDACinhibitor |
| Purity | >98%(HPLC);NMR(conforms) |
| CASNo. | 183506-66-3 |
| MolecularFormula | C34H49N5O6 |
| MolecularWeight | 623.8 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | Solublein10mg/mlDMSOor100%Ethanol |
| Source | Synthetic |
| Appearance | WhiteSolid |
| SMILES | CC[[email protected]](C)[[email protected]]1C(=O)N2CCCC[[email protected]@H]2C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC |
| InChI | InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-1 |
| InChIKey | JWOGUUIOCYMBPV-GMFLJSBRSA-N |
| SafetyPhrases | Classification:Toxic.Maybeharmfulorfatalifinhaled,swallowed,orabsorbedthroughskin.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-AvoidcontactwithskinandeyesHazardStatements:H300+H310–Fatalifswallowedorincontactwithskin.H330–FatalifinhaledPrecautionaryStatements:P260–Donotbreathedust/fumes/gas/mist/vapours/sprayP264-WashhandsthoroughlyafterhandlingP280–Wearprotectivegloves/ProtectiveclothingP284–WearrespiratoryprotectionP302+P350–Ifonskin:Gentlywashwithplentyofsoapandwater.P310–Immediatelycallapoisoncenterordoctor/physician |
| CiteThisProduct | Apicidin(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-346) |
BIOLOGicalDescription
| AlternativeNames | (3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone;Cyclo(N-O-methyl-L-tryptophanyl-LLisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl) |
| ResearchAreas | Cancer,CellSignaling,Epigenetics |
| PubChemID | 6918328 |
| ScientificBackground | Cyclopeptideinhibitorofhistonedeactylases(HDACs).InhibitsHeLacellproliferation(IC50=50-100nM)andinducesreversIBLetranscriptionalactivationofp21(WAF1).DecreasesHIF1αproteinlevelsandtranscriptionalactivityinhumanandmousetumorcelllines.Cellpermeable. |
| References | 1.Darkin-RattrayS.J.,etal.(1996)Proc.Natl.Acad.Sci.USA.93:13143. 2.HanJ.W.,etal.(2000)CancerRes.60:6068. 3.KimS.H.,etal.(2007)Oncol.Rep.17:647. |
ProductImages
ChemicalstructureofApicidin(SIH-346),aHDACinhibitor.CAS#:183506-66-3.MolecularFormula:C34H49N5O6.MolecularWeight:623.8g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
