StressMarq/Alsterpaullone/SIH-431-5MG/5-mg
商品编号：
SIH-431-5MG
市场价：
¥5500.00
美元价：
3300.00
产品分类：
酚
公司分类：
hydroxybenzene
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | Alsterpaullone |
| Description | CDK,GSKInhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 237430-03-4 |
| MolecularFormula | C16H11N3O3 |
| MolecularWeight | 293.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO;insolubleinwateror100%ethanol |
| Source | Synthetic |
| Appearance | Yellowtobrownpowder |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-] |
| InChI | InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20) |
| InChIKey | OLUKILHGKRVDCT-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Skinirritation(Category2),H315Eyeirritation(Category2A),H319Specifictargetorgantoxicity-singleexposure(Category3),Respiratorysystem,H335SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315Causesskinirritation.H319Causesseriouseyeirritation.H335Maycauserespiratoryirritation.Precautionarystatements:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P264Washskinthoroughlyafterhandling.P271Useonlyoutdoorsorinawell-ventilatedarea.P280Wearprotectivegloves/eyeprotection/faceprotection.P302+P352IFONSKIN:Washwithplentyofsoapandwater.P304+P340IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P332+P313Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313Ifeyeirritationpersists:Getmedicaladvice/attention.P362Takeoffcontaminatedclothingandwashbeforereuse.P403+P233Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405Storelockedup.P501Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | Alsterpaullone(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-431) |
BIOLOGicalDescription
| AlternativeNames | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 5005498 |
| ScientificBackground | AlsterpaulloneisapotentinhibitorofCDK1/cyclinB.ItisalsoapotentandselectiveinhibitorofGSK-3βandCDK5/p25.Alsterpaulloneinducesapoptosisbyactivatingcaspase-8andcaspase-9,followedbydisruptionofthemitochondrialpotential.Itiscell-permeable. |
| References | 1.ZaharevitzD.W.,etal.(1999).CancerResearch.59(11):2566–2569. 2.LahusenT.,DeSierviA.,KunickC.,&SenderowiczA.M.(2003)Mol.Carcinogenesis.36(4):183–194. 3.SchultzC.,etal.(1999)J.Med.Chem.42(15):2909–2919. |
ProductImages
ChemicalstructureofAlsterpaullone(SIH-431),aGSK3betakinaseinhibitor,CDK5/p25inhibitor.CAS#:237430-03-4.MolecularFormula:C16H11N3O3.MolecularWeight:293.3g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
