4000-520-616
欢迎来到免疫在线！(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
产品库 品牌馆 现货促销 技术交流 新闻动态 联系我们
StressMarq Biosciences
主营：主营：抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
咨询热线电话
4000-520-616
公司首页 公司介绍 产品中心 新闻动态 联系方式 在线下单
当前位置： 首页 > 产品中心 > hydroxybenzene > 应力MARQ/α-突触核蛋白/SPR-316E/500-微克
商品详细应力MARQ/α-突触核蛋白/SPR-316E/500-微克
应力MARQ/α-突触核蛋白/SPR-316E/500-微克
应力MARQ/α-突触核蛋白/SPR-316E/500-微克
商品编号： SPR-316E
市场价： ¥22100.00
美元价： 13260.00
产地： 美国(厂家直采)
公司：
产品分类： 酚
公司分类： hydroxybenzene
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
立即询价
商品介绍

Overview:

ProductNameAlphaSynucleinProtein
Description

HumanRecombinantAlphaSynucleinProteinMonomer(Control)

ApplicationsWB,SDS-PAGE,Invivoassay,Invitroassay
ConcentrationLot/batchspecific.Seeincludeddatasheet.
ConjugatesNotag

Properties

StorageBuffer0.2µmfilteredsolutionin20mMtris,150mMNaClpH7.5
StorageTemperature-80ºC
ShippingTemperatureBlueIceor4ºC
PurificationIon-exchangePurified
Specificity~14.46kDa
CiteThisProductHumanRecombinantAlphaSynucleinProtein(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SPR-316)
CertificateofAnalysisCertified92%pureusingSDS-PAGEanalysis.

BIOLOGicalDescription

AlternativeNamesAlphasynucleinmonomer,Alpha-synucleinmonomer,Alphasynucleinproteinmonomer,Alphasynucleinmonomer,Alpha-synucleinprotein,Non-AbetacomponentofADamyloidprotein,Non-A4componentofamyloidprecursorprotein,NACPprotein,SNCAprotein,NACPprotein,PARK1protein,Alphasynucleinmonomers,SYNprotein,Parkisondiseasefamilial1Protein
ResearchAreasAlzheimer"sDisease,Neurodegeneration,Neuroscience,Parkinson"sDisease
CellularLocalizationCytoplasm,Membrane,Nucleus
AccessionNumberNP_000336.1
GeneID6622
SwissProtP37840
ScientificBackgroundAlpha-Synuclein(SNCA)isexpressedpredominantlyinthebrain,whereitisconcentratedinpresynapticnerveterminals(1).Alpha-synucleinishighlyexpressedinthemitochondriaoftheolfactorybulb,hippocampus,striatumandthalamus(2).Functionally,ithasbeenshowntosignificantlyinteractwithtubulin(3),andmayserveasapotentialmicrotubule-associatedprotein.Ithasalsobeenfoundtobeessentialfornormaldevelopmentofthecognitivefunctions;inactivationmayleadtoimpairedspatiallearningandworkingmemory(4).SNCAfibrillaraggregatesrepresentthemajornonA-betacomponentofAlzheimersdiseaseamyloidplaque,andamajorcomponentofLewybodyinclusions,andParkinson’sdisease.Parkinson"sdisease(PD)isacommonneurodegenerativedisordercharacterizedbytheprogressiveaccumulationinselectedneuronsofproteininclusionscontainingalpha-synucleinandubiquitin(5,6).
References1.“GeneticsHomeReference:SNCA”.USNationalLibraryofMedicine.(2013).
2.ZhangL.,etal.(2008)BrainRes.1244:40-52.
3.AlimM.A.,etal.(2002)JBiolChem.277(3):2112-2117.
4.KokhanV.S.,AfanasyevaM.A.,Van’kinG.(2012)Behav.Brain.Res.231(1):226-230.
5.SpillantiniM.G.,etal.(1997)Nature.388(6645):839-840.
6.MezeyE.,etal.(1998)NatMed.4(7):755-757.

ProductImages

<p>SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Monomer (Control) (SPR-316). Lane 1: Molecular Weight Ladder (MW). Lane 2: BSA (2.5 µg). Lane 3: BSA (5 µg). Lane 4: Alpha Synuclein Protein Monomer (2.5 µg) (SPR-316). Lane 5: Alpha Synuclein Protein Monomer (5 µg) (SPR-316).</p>

SDS-PAGEof~14kDaHumanRecombinantAlphaSynucleinProteinMonomer(Control)(SPR-316).Lane1:MolecularWeightLadder(MW).Lane2:BSA(2.5µg).Lane3:BSA(5µg).Lane4:AlphaSynucleinProteinMonomer(2.5µg)(SPR-316).Lane5:AlphaSynucleinProteinMonomer(5µg)(SPR-316).

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of active alpha Synuclein aggregate (SPR-322). Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofactivealphaSynucleinaggregate(SPR-322).ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to active alpha Synuclein aggregate (SPR-322) and active alpha Synuclein monomer (SPR-321) alone. Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtoactivealphaSynucleinaggregate(SPR-322)andactivealphaSynucleinmonomer(SPR-321)alone.ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of active alpha Synuclein monomer (SPR-321) is combined with 10 nM of control alpha Synuclein aggregate (SPR-317), or 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of control alpha Synuclein aggregate (SPR-317). Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofactivealphaSynucleinmonomer(SPR-321)iscombinedwith10nMofcontrolalphaSynucleinaggregate(SPR-317),or100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofcontrolalphaSynucleinaggregate(SPR-317).ThioflavinTex=450nm,em=485nm.

<p>Active alpha synuclein aggregate (SPR-322) seeds the formation of new alpha Synuclein aggregates from the pool of active alpha Synuclein monomers (SPR-321). Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha Synuclein aggregates. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to alpha Synuclein protein aggregation) over time when 10 nM of active alpha Synuclein aggregate (SPR-322) is combined with 100 µM of active alpha Synuclein monomer (SPR-321), as compared to when 100 µM of control alpha Synuclein monomer (SPR-316) is combined with 10 nM of active alpha Synuclein aggregate (SPR-322), or active alpha Synuclein aggregate (SPR-322) and active alpha Synuclein monomer (SPR-321) alone. Thioflavin T ex = 450 nm, em = 485 nm.</p>

Activealphasynucleinaggregate(SPR-322)seedstheformationofnewalphaSynucleinaggregatesfromthepoolofactivealphaSynucleinmonomers(SPR-321).ThioflavinTisafluorescentdyethatbindstobetasheet-richstructures,suchasthoseinalphaSynucleinaggregates.Uponbinding,theemissionspectrumofthedyeexperiencesared-shift,andincreasedfluorescenceintensity.ThioflavinTemissioncurvesshowincreasedfluorescence(correlatedtoalphaSynucleinproteinaggregation)overtimewhen10nMofactivealphaSynucleinaggregate(SPR-322)iscombinedwith100µMofactivealphaSynucleinmonomer(SPR-321),ascomparedtowhen100µMofcontrolalphaSynucleinmonomer(SPR-316)iscombinedwith10nMofactivealphaSynucleinaggregate(SPR-322),oractivealphaSynucleinaggregate(SPR-322)andactivealphaSynucleinmonomer(SPR-321)alone.ThioflavinTex=450nm,em=485nm.

ProductCitations(0)

Currentlytherearenocitationsforthisproduct.

品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
品牌分类
CLIA套件 兴奋剂 敌手 抑制剂 蛋白质 活化剂 抗氧化剂 氧化还原探针 多克隆
显示分类
联络我们
服务热线：4000-520-616
（限工作日9:00-18:00）
QQ ：1570468124
手机：18915418616
快速导航：
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏  0512-67156496（苏州）
版权信息：
©  2015-2022 苏州蚂蚁淘生物科技有限公司 版权所有 中国
网站备案：
友情链接：
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。
扫描二维码关注官方微信
获取最新促销及产品信息