应力MARQ/AICAR/SIH-402-10MG/10MG
商品编号：
SIH-402-10MG
市场价：
¥1100.00
美元价：
660.00
产品分类：
酚
公司分类：
hydroxybenzene
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | AICAR |
| Description | Autophagyinducer |
| Purity | >99%(TLC),NMRconforms |
| CASNo. | 2627-69-2 |
| MolecularFormula | C9H14N4O5 |
| MolecularWeight | 258.2 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inducer |
| Solubility | Solubleto75mMinwaterandto75mMinDMSO. |
| Source | Synthetic |
| Appearance | Off-whitesolid. |
| SMILES | [[email protected]@H]2([N]1C(=C(C(N)=O)N=C1)N)O[[email protected]](CO)[[email protected]]([[email protected]]2O)O |
| InChI | InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| SafetyPhrases | Classification:D2B-ToxicMaterialCausingOtherToxicEffects,Moderateskinirritant,Moderaterespiratoryirritant,ModerateeyeirritantSafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H315-Causesskinirritation.H319-Causesseriouseyeirritation.H335-Maycauserespiratoryirritation.Precautionarystatements:P261-Avoidbreathingdust/fume/gas/mist/vapours/spray.P264-Washskinthoroughlyafterhandling.P271-Useonlyoutdoorsorinawell-ventilatedarea.P280-Wearprotectivegloves/eyeprotection/faceprotection.P302+P352-IFONSKIN:Washwithplentyofsoapandwater.P304+P340-IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing.P305+P351+P338-IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.Continuerinsing.P312-CallaPOISONCENTERordoctor/physicianifyoufeelunwell.P321-Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P332+P313-Ifskinirritationoccurs:Getmedicaladvice/attention.P337+P313-Ifeyeirritationpersists:Getmedicaladvice/attention.P362-Takeoffcontaminatedclothingandwashbeforereuse.P403+P233-Storeinawell-ventilatedplace.Keepcontainertightlyclosed.P405-Storelockedup.P501-Disposeofcontents/containertoanapprovedwastedisposalplant. |
| CiteThisProduct | AICAR(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-402) |
BIOLOGicalDescription
| AlternativeNames | N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
| ResearchAreas | Cancer,Autophagy |
| PubChemID | 17513 |
| ScientificBackground | AICARisanadenosineanalogthatwhenphosphorylatedforms5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate(ZMP)whichproceedstoactivateadenosinemonophosphate-activatedproteinkinase(AMPK).Thisprocessinturnstimulatesglucoseuptakebyskeletalmuscleinaninsulin-dependentmanner.AutophagyisinitiatedbytheUNC-51-likekinase1/2complex(ULK1andULK2).Underbasalconditions,autophagyisnegativelyregulatedduetothephosphorylationofULK1atserine-757bymTORC1.Duringstarvation,autophagyispositivelyregulatedbyULK1/2whenitisphosphorylatedatserine-555andserine-777byAMPK.Therefore,theactivationofAMPKbyAICAR,inturnwillinduceautophagy. |
| References | 1.JhunB.S.,etal.(2004)BiochemBiophysResCommun.318(2):372-80. 2.HuangH.,etal.(2013)Autophagy.9(2):175-95. |
ProductImages
ChemicalstructureofAICAR(SIH-402),aAutophagyinducer.CAS#:2627-69-2.MolecularFormula:C9H14N4O5.MolecularWeight:258.2g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
