StressMarq/AG490/SIH-428-25MG/25-mg
商品编号：
SIH-428-25MG
市场价：
¥3900.00
美元价：
2340.00
产品分类：
酚
公司分类：
hydroxybenzene
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | AG490 |
| Description | JAK-2kinaseinhibitor |
| Purity | >98%(TLC) |
| CASNo. | 133550-30-8 |
| MolecularFormula | C17H14N2O3 |
| MolecularWeight | 294.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(30mg/ml),dimethylformamide(40mg/ml)or100%ethanol(10mg/ml) |
| Source | Synthetic |
| Appearance | Tansolid |
| SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| SafetyPhrases | Classification:Acutetoxicity,Oral(Category3),H301Acuteaquatictoxicity(Category1),H400Chronicaquatictoxicity(Category1),H410SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection.Hazardstatements:H301Toxicifswallowed.H410Verytoxictoaquaticlifewithlonglastingeffects.Precautionarystatements:P264Washskinthoroughlyafterhandling.P270Donoteat,drinkorsmokewhenusingthisproduct.P273Avoidreleasetotheenvironment.P301+P310IFSWALLOWED:ImmediatelycallaPOISONCENTERordoctor/physician.P321Specifictreatment(seesupplementalfirstaidinstructionsonthislabel).P330Rinsemouth.P391Collectspillage.P405Storelockedup. |
| CiteThisProduct | AG490(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-428) |
BIOLOGicalDescription
| AlternativeNames | TyrphostinAG490,N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide,2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide,2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 5328779 |
| ScientificBackground | AG490isaselectiveinhibitorofJAK2/3andEGFreceptortyrosinekinase.ItalsoinhibitsthedownstreamactivationofSTAT5a/b.AG490iscellpermeableandisavaluabletoolforstudyingthecellularroleofJAKkinasesinsignaltransduction. |
| References | 1.AbeM.,etal.(2009)Int.Immunopharma.9(7-8):870–877. 2.DeVosJ.,JourdanM.,TarteK.,JasminC.,&KleinB.(2000)BritishJ.Haem.109(4):823–828. 3.KirkenR.A.,etal.(1999)J.LeukocyteBiol.65(6):891–899. |
ProductImages
ChemicalstructureofAG490(SIH-428),aJAK-2kinaseinhibitor.CAS#:133550-30-8.MolecularFormula:C17H14N2O3.MolecularWeight:294.3g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
