StressMarq/AG 1478/SIH-425-5MG/5-mg
商品编号：
SIH-425-5MG
市场价：
¥1600.00
美元价：
960.00
产品分类：
酚
公司分类：
hydroxybenzene
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | AG1478 |
| Description | EGFRkinaseinhibitor |
| Purity | >98%(HPLC) |
| CASNo. | 153436-53-4 |
| MolecularFormula | C16H14ClN3O2 |
| MolecularWeight | 315.8 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(10mg/ml) |
| Source | Synthetic |
| Appearance | Whitetolightyellowsolid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| InChI | InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h4-9H,1-2H3,(H,18,19,20) |
| InChIKey | GFNNBHLJANVSQV-UHFFFAOYSA-N |
| SafetyPhrases | Classification:Notahazardoussubstanceormixture.SafetyPhrases:S22-Donotbreathedust.S24/25-Avoidcontactwithskinandeyes.S36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection. |
| CiteThisProduct | AG1478(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-425) |
BIOLOGicalDescription
| AlternativeNames | N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine,4-(3-Chloroanilino)-6,7-dimethoxyquinazoline |
| ResearchAreas | Cancer,Apoptosis,CancerGrowthInhibitors,CellSignaling,TyrosineKinaseInhibitors |
| PubChemID | 2051 |
| ScientificBackground | AG1478isapotentandselectiveinhibitorofEGFR.ItdoessobyreducingEGF-stimulatedDNAsynthesis(seeninratfibroblasts)andblockingEGF-dependentsrc-familykinaseactivationandp21/Cip1/WAF1induction(seeninA431cells).AG1478iscell-permeableandactiveinvivo. |
| References | 1.OsherovN.,&LevitzkiA.(1994)EuroJ.Biochem.225(3):1047–1053. 2.MiyazakiY.,etal.(1996)Biochem.Biophys.ResearchComm.226(2):542–546. 3.FanZ.,etal.(1995)JCellBiol.131(1):235–242. |
ProductImages
ChemicalstructureofAG1478(SIH-425),aEGFRkinaseinhibitor.CAS#:175178-82-2.MolecularFormula:C16H14ClN3O2.MolecularWeight:315.8g/mol.
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品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
