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当前位置： 首页 > 产品中心 > Electrophoretic_buffer > StressMarq/Anti-Abl1 Antibody (pTyr469)/SPC-905D-A390/100-µl
商品详细StressMarq/Anti-Abl1 Antibody (pTyr469)/SPC-905D-A390/100-µl
StressMarq/Anti-Abl1 Antibody (pTyr469)/SPC-905D-A390/100-µl
StressMarq/Anti-Abl1 Antibody (pTyr469)/SPC-905D-A390/100-µl
商品编号： SPC-905D-A390
市场价： ¥6860.00
美元价： 4116.00
产地： 美国(厂家直采)
公司：
产品分类： 电泳缓冲液
公司分类： Electrophoretic_buffer
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name Abl1 Antibody (pTyr469)
Description

Rabbit Anti-Human Abl1 (pTyr469) Polyclonal

Species Reactivity Human
Applications WB, AM
Antibody Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A phospho-specific peptide corresponding to residues surrounding Tyr469 of human Abl1 (AA466-472)
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Peptide Affinity Purified
Clonality Polyclonal
Specificity Detects 122.945 kDa.
Cite This Product StressMarq Biosciences Cat# SPC-905, RRID: AB_2706689
Certificate of Analysis A 1:250 dilution of SPC-905 was sufficient for detection of Abl1 (pTyr469) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names Abelson tyrosine protein kinase 1 Antibody, ABL Antibody, c ABL Antibody, p150 Antibody, bcr/abl Antibody
Research Areas Cancer, Cell Signaling, Epigenetics and Nuclear Signaling, Oncoproteins, Protein Phosphorylation, Transcription, Tumor Biomarkers, Tyrosine Kinases
Cellular Localization Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus
Accession Number NP_005148
Gene ID 25
Swiss Prot P00519
Scientific Background ABL1 is a widely-expressed, non-receptor protein-tyrosine kinase. It is stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. It is activated by autophosphorylation as well as by Src-family kinase-mediated phosphorylation. It can also be activated by RIN1 binding to the SH2 and SH3 domains. As it is stimulated by cell death inducers and DNA-damage, it is likely that the wild-type form of Abl1 is actually a tumour -suppressor protein. The normal active form of Abl1 is nuclear, and it is sequestered into the cytoplasm by interaction with 14-3-3 through Thr-735. It localizes to the mitochondria under conditions of oxidative stress.

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  ATTO 390
Overview:

  • High fluorescence yield
  • Large Stokes-shift (89 nm)
  • Good photostability
  • Moderately hydrophilic
  • Good solubility in polar solvents
  • Coumarin derivate, uncharged
  • Low molar mass: 343.42 g/mol 

ATTO 390 Datasheet

ATTO 390 Fluorescent Dye Excitation and Emission SpectraOptical Properties:

λex = 390 nm

λem = 479 nm

εmax = 2.4×104

Φf = 0.90

τfl = 5.0 ns

Brightness = 21.6

Laser = 365 or 405 nm

 

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StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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