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当前位置： 首页 > 产品中心 > Electrophoretic_buffer > StressMarq/Anti-ABCG2 Antibody/SPC-1317D/100-µl
商品详细StressMarq/Anti-ABCG2 Antibody/SPC-1317D/100-µl
StressMarq/Anti-ABCG2 Antibody/SPC-1317D/100-µl
StressMarq/Anti-ABCG2 Antibody/SPC-1317D/100-µl
商品编号： SPC-1317D
市场价： ¥5100.00
美元价： 3060.00
产地： 美国(厂家直采)
公司：
产品分类： 电泳缓冲液
公司分类： Electrophoretic_buffer
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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商品介绍

Overview:

Product Name ABCG2 Antibody
Description

Rabbit Anti-Human ABCG2 Polyclonal

Species Reactivity Human
Applications WB, IHC
Antibody Dilution WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Host Species Rabbit
Immunogen Species Human
Immunogen A synthesized peptide derived from human ABCG2
Conjugates Alkaline Phosphatase, APC, ATTO 390, ATTO 488, ATTO 565, ATTO 594, ATTO 633, ATTO 655, ATTO 680, ATTO 700, Biotin, FITC, HRP, PE/ATTO 594, PerCP, RPE, Streptavidin, Unconjugated

Properties

Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Purification Affinity Purified
Clonality Polyclonal
Isotype IgG
Specificity Detects endogenous levels of total ABCG2
Cite This Product StressMarq Biosciences Cat# SPC-1317, RRID: AB_2713493
Certificate of Analysis A 1:1000 dilution of SPC-1317 was sufficient for detection of ABCG2 in 10 µg of mouse kidney cell lyates by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Biological Description

Alternative Names ABC transporter antibody ABC15 antibody ABCG 2 antibody ABCG2 antibody ABCG2_HUMAN antibody ABCP antibody ATP binding cassette sub family G (WHITE) member 2 antibody ATP binding cassette transporter G2 antibody ATP-binding cassette sub-family G member 2 antibody BCRP antibody BCRP1 antibody BMDP antibody Breast cancer resistance protein antibody CD338 antibody CDw338 antibody CDw338 antigen antibody EST157481 antibody GOUT1 antibody MGC102821 antibody Mitoxantrone resistance associated protein antibody Mitoxantrone resistance-associated protein antibody MRX antibody Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2 antibody MXR antibody MXR1 antibody Placenta specific ATP binding cassette transporter antibody Placenta specific MDR protein antibody Placenta-specific ATP-binding cassette transporter antibody UAQTL1 antibody
Cellular Localization Cell membrane, Mitochondrion membrane
Accession Number NP_004818.2
Gene ID 9429
Swiss Prot Q9UNQ0
Scientific Background ABCG2 (BCRP1/ABCP/MXR) is a member of the ATP-binding cassette transporter family that functions as ATP-dependent transporters for a wide variety of chemical compounds and are associated with drug-resistance in cancer cells. ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane spanning regions consistent with it functioning as a half-transporter. The ABC family can exist as either full-length transporters or as half-transporters that form functional transporters through homo- or heterodimerization. Originally thought to play a role in drug resistance due to its resistance to a number of chemotherapeutic drugs, ABCG2 has also been found in the kidney, and stem cell populations. Studies also suggest that it can be used as a cell surface marker to identify hematopoietic stem cells within the bone marrow fraction of lineage negative cells. The expression of ABCG2 appears greatest on CD34- cells and is downregulated with the acquisition of CD34 on the cell surface.
References 1. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.
2. Doyle L.A. and Ross D.D. (2003) Oncogene. 22: 7340-58.
3. Allen J.D. et al. (1999) Cancer Res. 59: 4237-41.
4. Doyle L.A., et al. (1998) Proc Natl Acad Sci USA. 95: 15665-70.
5. Allikmets R., et al. (1998) Cancer Res. 58: 5337-9.
6. Miyake K., et al. (1999) Cancer Res. 59: 8-13.
7. Robey R.W., et al. (2001) Clin Cancer Res. 7: 145-52. Zhou S., et al. (2001) Nat. Medicine. 7: 1028.

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StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
公司介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒
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