StressMarq/A-967079/SIH-301-50MG/50-mg
商品编号：
SIH-301-50MG
市场价：
¥7600.00
美元价：
4560.00
产品分类：
电泳缓冲液
公司分类：
Electrophoretic_buffer
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview:
| ProductName | A-967079 |
| Description | TRPA1blocker |
| Purity | >98% |
| CASNo. | 1170613-55-4 |
| MolecularFormula | C12H14FNO |
| MolecularWeight | 207.3 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(25mg/ml) |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | CC/C(=NO)/C(=C/C1=CC=C(C=C1)F)/C |
| InChI | InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+ |
| InChIKey | HKROEBDHHKMNBZ-CHBKHGQFSA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionHazardPhrases:H302-H315-H317-H318-H335PrecautionaryPhrases:P261-P280-P305+P351+P338 |
| CiteThisProduct | A-967079(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-301) |
BIOLOGicalDescription
| AlternativeNames | (1E,3E)-1-(4-Fluorophenyl)-N-hydroxy-2-methyl-1-penten-3-imine |
| ResearchAreas | IonChannels,Neuroscience,TransientReceptorPotentialChannels |
| PubChemID | 42641861 |
| ScientificBackground | A-967079isaTRPA1antagonist(1)andcellpermeable.IthasbeenfoundtobeapotentblockerofTRPA1channels.ItisanoximeanalogueandresemblesAP18fromastructuralperspective,althoughithasamethyladditionandachlorine–fluorinesubstitution.However,comparedwithAP18andHC-030031,A-967079issignificantlymorepotent(100-foldonhumanand24-foldonratTRPA1)andhasamuchimprovedpharmacokineticprofile.A-967079isalsomoreselective,with>1000-foldselectivityoverotherTRPchannelsand>150-foldselectivityover75othertestedproteins(2). |
| References | 1.McGaraughtyS.,etal.(2010)MolPain.6:14.2.Chenetal.(2011)PAIN.152:1165–1172. |
ProductImages
ChemicalstructureofA-967079(SIH-301),aTRPA1blocker.CAS#:1170613-55-4.MolecularFormula:C12H14FNO.MolecularWeight:207.3g/mol.
ProductCitations(1)
OtherCitations
Lysophosphatidicacid-induceditchismediatedbysignalingofLPA5receptor,phospholipaseDandTRPA1/TRPV1.
Kittaka,H.,Uchida,K.,Fukuta,N.andTominaga,M.(2017)JPhysiol.595(8):2681-2698.
PubMedID:28176353Applications:Invitroinhibition
品牌介绍
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究，同时在其他领域也取得了一定成就，包括翻译后修饰，提供甲基化与乙酰基化抗体。其中，细胞应激领域主要包括热休克蛋白（HSP）领域。我们公司不仅在热休克蛋白领域领先全球，而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列，分别涉及抗体、蛋白、酶联免疫吸附试验（ELISA）试剂盒及小分子领域。
